Intra-islet endothelial cell and β-cell crosstalk: Implication for islet cell transplantation
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چکیده
منابع مشابه
Intra-islet endothelial cell and β-cell crosstalk: Implication for islet cell transplantation
The intra-islet microvasculature is a critical interface between the blood and islet endocrine cells governing a number of cellular and pathophysiological processes associated with the pancreatic tissue. A growing body of evidence indicates a strong functional and physical interdependency of β-cells with endothelial cells (ECs), the building blocks of islet microvasculature. Intra-islet ECs, ac...
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Currently, for the patient with type 1 diabetes, a definitive treatment without resorting to the use of exogenous insulin can be achieved only with pancreas or islet cell transplantation. These means of restoring beta-cell mass can completely maintain essentially normal long-term glucose homeostasis, although the need for powerful immunosuppressive regimens limits their application to only a su...
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Restoration of physiologic metabolic control is the ultimate therapeutic goal for patients with diabetes but is difficult to achieve by means of medical therapy. Transplantation of islets of Langerhans represents a viable therapeutic option for patients with insulin-dependent diabetes. It is currently offered to patients with a brittle form of diabetes and hypoglycemia unawareness. Current limi...
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Islet cell transplantation has been associated with ultimate graft rejection. This preliminary study investigates the use of the renal subcapsular region as a site for placement of canine islet cell allografts. A new noncollagenase mechanical technique was used for preparation of the allografts. Animals in group I (N = 6) died of hyperglycemia in 4.0 +/- 1.89 days (X +/- SD) after pancreatectom...
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SubtotaJ pancreatectomy with preservation of the duodenum was performed in two mongrel dogs weighing 12 and 13.5 kg. The islets were separated by collagenase digestion (Boehringer-Mannheim P, Mannheim. Germany 1.5 mg/mL) using the automated method and purified on Eurocollins-Ficoll discontinuous gradients.2 The final preparation comprised approximately 291,000 and 146,000 islets with an average...
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ژورنال
عنوان ژورنال: World Journal of Transplantation
سال: 2017
ISSN: 2220-3230
DOI: 10.5500/wjt.v7.i2.117